Publications
Cristina Aguayo- Mazzucato
Joslin Diabetes Center
cristina.aguayo-mazzucato@joslin.harvard.es
www.betacellaginglab.com
Unique human and mouse β-cell senescence-associated secretory phenotype (SASP) reveal conserved signaling pathways and heterogeneous factors. Diabetes. 2021 Mar
Midha A, Pan H, Abarca C, Andle J, Carapeto P, Bonner-Weir S, Aguayo-Mazzucato C.
Functional changes in beta cells during ageing and senescence. Diabetologia. 2020 Oct
Aguayo-Mazzucato C.
Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. Cell Metab. 2019 Jul
Aguayo-Mazzucato C., Andle J, Lee TB Jr, Midha A, Talemal L, Chipashvili V, Hollister-Lock J, van Deursen J, Weir G, Bonner-Weir S.
Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance. medRxiv . 2021 Mar
Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Rubio-Navarro A, Uhl S, Shukla AP, Goyal P, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC.
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells. Biol Chem. 2020 Oct
Sharma RB, Darko C, Alonso LC.
Continuous glucose monitoring reduces pubertal hyperglycemia of type 1 diabetes. Pediatr Endocrinol Metab. 2020 Jul
Nwosu BU, Yeasmin S, Ayyoub S, Rupendu S, Villalobos-Ortiz TR, Jasmin G, Parajuli S, Zahedi B, Zitek-Morrison E, Alonso LC, Barton BA.
Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability. Mol Metab. 2020 May
Ebrahimi AG, Hollister-Lock J, Sullivan BA, Tsuchida R, Bonner-Weir S, Weir GC.
Residual β cell function and monogenic variants in long-duration type 1 diabetes patients. J Clin Invest. 2019 Jul
Yu MG, Keenan HA, Shah HS, Frodsham SG, Pober D, He Z, Wolfson EA, D'Eon S, Tinsley LJ, Bonner-Weir S, Pezzolesi MG, King GL.
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 Jul.
Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE.
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018 Feb.
Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA, Li H, Breault DT, Ingber DE.
Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 Jan.
Richmond CA, Rickner H, Shah MS, Ediger T, Deary L, Zhou F, Tovaglieri A, Carlone DL, Breault DT.
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 Dec
Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS.
Targeting Pyruvate Kinase PEPs Up Insulin Secretion and Improves Glucose Homeostasis. Cell Metab. 2020 Nov
Corkey BE
Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration. iScience. 2020 Feb
Rumala CZ, Liu J, Locasale JW, Corkey BE, Deeney JT, Rameh LE.
TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation. J Mol Endocrinol. 2021 Apr
Kahraman S, Yilmaz O, Altunbas HA, Dirice E, Sanlioglu AD
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells. Life Sci Alliance. 2021 Jan
Kahraman S, Manna D, Dirice E, Maji B, Small J, Wagner BK, Choudhary A, Kulkarni RN.
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 May
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN
GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice. Front Immunol. 2021 Feb
Efimova I, Steinberg I, Zvibel I, Neumann A, Mantelmacher DF, Drucker DJ, Fishman S, Varol C.
Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans. Nat Commun. 2020 Jul
Baggio LL, Varin EM, Koehler JA, Cao X, Lokhnygina Y, Stevens SR, Holman RR, Drucker DJ.
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metab. 2018 Apr
Drucker DJ.
Abdelafattah El Ouaamari
Rutgers Robert Wood Johnson Medical School
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 May
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN.
Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation. Cell Metab. 2017 Apr
Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN. I
SerpinB1 Promotes Pancreatic β Cell Proliferation. Cell Metab. 2016 Jan
El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN.
Mathieu Ferron
Institut de recherches cliniques de Montréal (IRCM)
mathieu.ferron@ircm.qc.ca
www.ircm.qc.ca/en/research/cardiovascular-and-metabolic-diseases/
The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans. eLife. 2020.
Al Rifai, O., Julien, C., Lacombe, J., Faubert, D., Lira-Navarrete, E., Narimatsu, Y., J., L., Clausen, H., Ferron, M..
Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and ?-cell function. Am J Physiol Endocrinol Metab. 2020
Lacombe J., Al Rifai, O., Loter, L., Moran, T., Turcotte, A.F., Grenier-Larouche, T., Tchernof, A., Biertho, L., Carpentier, A.C., Prud'homme, D., Rabasa-Lhoret, R., Karsenty, G., Gagnon, C., Jiang, W., Ferron, M.
Proprotein convertase furin regulates osteocalcin and bone endocrine function. J Clin Invest. 2017
Al Rifai, O., Chow, J., Lacombe, J., Julien, C., Faubert, D., Susan-Resiga, D., Essalmani, R., Creemers, J.W., Seidah, N.G., Ferron, M*.
Adolfo Garcia-Ocana
Icahn School of Medicine at Mount Sinai
adolfo.garcia-ocana@mssm.edu
www.labs.icahn.mssm.edu/garciaocana-lab/
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes. J Med Chem. 2021 Mar
Kumar K, Suebsuwong C, Wang P, Garcia-Ocana A, Stewart AF, DeVita RJ
GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells. JCI Insight. 2021 Feb
Saikia M, Holter MM, Donahue LR, Lee IS, Zheng QC, Wise JL, Todero JE, Phuong DJ, Garibay D, Coch R, Sloop KW, Garcia-Ocana A, Danko CG, Cummings BP.
GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells. JCI Insight. 2021 Feb
Saikia M, Holter MM, Donahue LR, Lee IS, Zheng QC, Wise JL, Todero JE, Phuong DJ, Garibay D, Coch R, Sloop KW, Garcia-Ocana A, Danko CG, Cummings BP.
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 Nov
Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R.
Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency. Mol Ther. 2017 Nov
Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C.
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017 Aug
Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC.
Decreased pancreatic acinar cell number in type 1 diabetes. Diabetologia. 2020 Jul
Wright JJ, Saunders DC, Dai C, Poffenberger G, Cairns B, Serreze DV, Harlan DM, Bottino R, Brissova M, Powers AC.
Proteomic and Transcriptional Profiles of Human Stem Cell-Derived β Cells Following Enteroviral Challenge. Microorganisms. 2020 Feb 20
Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP.
Type 1 Diabetes TrialNet Study Group. Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. Sci Transl Med. 2021 Mar
Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC
Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors. Clin Oncol Case Rep. 2020 Nov
Perdigoto AL, Tran T, Patel N, Clark P, Patell K, Stamatouli AM, Reddy V, Clune J, Herold KC, Robert ME, Kluger HM.
Type 1 Diabetes TrialNet Study Group. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 Aug
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ
George G. Holz
Upstate Medical University
holzg@upstate.edu
www.upstate.edu/endo/research/laboratory-research/holz.php
Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis. J Med Chem. 2021 Jan
Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, Hayes MR, De Jonghe BC, Holz GG, Roth CL, Doyle RP.
Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4. J Med Chem. 2021 Mar
Tinsley IC, Borner T, Swanson ML, Chepurny OG, Doebley SA, Kamat V, Sweet IR, Holz GG, Hayes MR, De Jonghe BC, Doyle RP.
FRET Reporter Assays for cAMP and Calcium in a 96-well Format Using Genetically Encoded Biosensors Expressed in Living Cells. Bio Protoc. 2020 Jun
Milliken BT, Doyle RP, Holz GG, Chepurny OG.
Thomas Jetton
The University of Vermont
tjetton@uvm.edu
www.med.uvm.edu/medicine/endocrinology/research_jetton-lab
Facility-dependent metabolic phenotype and gut bacterial composition in CD-1 mice from a single vendor: A brief report. PLoS One. 2020 Sep
Unger AL, Eckstrom K, Jetton TL, Kraft J.
Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality. PLoS One. 2019
Unger AL, Eckstrom K, Jetton TL, Kraft J.
β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation. J Biol Chem. 2018
Gupta D, Lacayo AA, Greene SM, Leahy JL, Jetton TL.
BBB pathophysiology-independent delivery of siRNA in traumatic brain injury. Sci Adv. 2021 Jan
Li W, Qiu J, Li XL, Aday S, Zhang J, Conley G, Xu J, Joseph J, Lan H, Langer R, Mannix R, Karp JM, Joshi N.
A cell-based drug delivery platform for treating central nervous system inflammation. J Mol Med (Berl). 2021 May
Levy O, Rothhammer V, Mascanfroni I, Tong Z, Kuai R, De Biasio M, Wang Q, Majid T, Perrault C, Yeste A, Kenison JE, Safaee H, Musabeyezu J, Heinelt M, Milton Y, Kuang H, Lan H, Siders W, Multon MC, Rothblatt J, Massadeh S, Alaamery M, Alhasan AH, Quintana FJ, Karp JM.
Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors. Mol Cancer Ther. 2021 Feb
Chaudagar KK, Landon-Brace N, Solanki A, Hieromnimon HM, Hegermiller E, Li W, Shao Y, Joseph J, Wilkins DJ, Bynoe KM, Li XL, Clohessy JG, Ullas S, Karp JM, Patnaik A.
NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart. Front Immunol. 2020 Dec
Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin SE, Hollmann MW, Weber NC, Houten SM, van Weeghel M, Kibbey RG, Zuurbier CJ.
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health. Cell Metab. 2020 Nov
Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG.
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway. Cell Metab. 2020 Nov
Lewandowski SL, Cardone RL, Foster HR, Ho T, Potapenko E, Poudel C, VanDeusen HR, Sdao SM, Alves TC, Zhao X, Capozzi ME, de Souza AH, Jahan I, Thomas CJ, Nunemaker CS, Davis DB, Campbell JE, Kibbey RG, Merrins MJ.
Rohit Kulkarni
Joslin Diabetes Center
Rohit.Kulkarni@joslin.harvard.edu
www.joslin.theopenscholar.com/kulkarni-lab
Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice. J Biol Chem. 2021 Apr
Takatani T, Shirakawa J, Shibue K, Gupta MK, Kim H, Lu S, Hu J, White MF, Kennedy RT, Kulkarni RN.
Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation. J Biol Chem. 2021 Mar
Keong Teo AK, Nguyen L, Gupta MK, Lau HH, Weng Loo LS, Jackson N, Lim CS, Mallard W, Gritsenko MA, Rinn JL, Smith RD, Qian WJ, Kulkarni RN.
Epigenetics in β-cell adaptation and type 2 diabetes. Curr Opin Pharmacol. 2020 Dec
Kim H, Kulkarni RN.
John Leahy
The University of Vermont
john.leahy@uvm.edu
Sodium-Glucose Cotransporter 2 Inhibitor Protection Against Adverse Cardiovascular and Renal Outcomes in Patients With Type 2 Diabetes. Clin Diabetes. 2019 Jul
Shahady E, Leahy JL.
Temporal characterization of β cell-adaptive and -maladaptive mechanisms during chronic high-fat feeding in C57BL/6NTac mice. J Biol Chem. 2017 Jul
Gupta D, Jetton TL, LaRock K, Monga N, Satish B, Lausier J, Peshavaria M, Leahy JL.
β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation. J Biol Chem. 2018 Dec
Gupta D, Lacayo AA, Greene SM, Leahy JL, Jetton TL.
Douglas A. Melton
Harvard Stem Cell Institute
dmelton@harvard.edu
www.hscrb.harvard.edu/labs/melton-lab/
Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Cell Rep. 2020 Jul
Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA.
Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nat Commun. 2016 Aug
Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA.
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Mar
Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG.
Jerry Nadler
Eastern Virgina Medical School
nadlerjl@evms.edu
Proteomic and Transcriptional Profiles of Human Stem Cell-Derived β Cells Following Enteroviral Challenge. Microorganisms. 2020 Feb
Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP.
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D. Transl Res. 2019 Nov
Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C.
Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care. 2019 May
Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C.
Vincent Poitout
University of Montreal
vincent.poitout@umontreal.ca
Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Mol Metab. 2021 Mar
Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Castillo VC, Campbell SA, Ghislain J, Huising MO, Poitout V.
A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. Physiol Rep. 2019 Oct
Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE.
The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats. Am J Physiol Endocrinol Metab. 2019 Aug
Moullé VS, Tremblay C, Castell AL, Vivot K, Ethier M, Fergusson G, Alquier T, Ghislain J, Poitout V.
Marc Prentki
University of Montreal
Elevated Expression of Glycerol-3-Phosphate Phosphatase as a Biomarker of Poor Prognosis and Aggressive Prostate Cancer. Cancers (Basel). 2021 Mar
Lounis MA, Ouellet V, Péant B, Caron C, Li Z, Al-Mass A, Madiraju SRM, Mes-Masson AM, Prentki M, Saad F.
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 Dec
Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS.
microRNA-375 regulates glucose metabolism-related signaling for insulin secretion. J Endocrinol. 2020 Jan
Dumortier O, Fabris G, Pisani DF, Casamento V, Gautier N, Hinault C, Lebrun P, Duranton C, Tauc M, Dalle S, Kerr-Conte J, Pattou F, Prentki M, Van Obberghen E.
Donald Scott
Icahn School of Medicine at Mount Sinai
donald.scott@mssm.edu
www.labs.icahn.mssm.edu/scottlab/
The Many Lives of Myc in the Pancreatic β-Cell. J Biol Chem. 2020 Nov
Rosselot C, Baumel-Alterzon S, Li Y, Brill G, Lambertini L, Katz LS, Lu G, García-Ocaña A, Scott DK.
HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats. Diabetes. 2020 Ma
Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, Metukuri MR, Scott DK, Ghislain J, Poitout V.
Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors. JCI Insight. 2020 Jan
Ackeifi C, Swartz E, Kumar K, Liu H, Chalada S, Karakose E, Scott DK, Garcia-Ocaña A, Sanchez R, DeVita RJ, Stewart AF, Wang P.
Andrew Stewart
Icahn School of Medicine at Mount Sinai
andrew.stewart@mssm.edu
https://labs.icahn.mssm.edu/stewartlab/
Aberrant methylation underlies insulin gene expression in human insulinoma. Nat Commun. 2020 Oct
Karakose E, Wang H, Inabnet W, Thakker RV, Libutti S, Fernandez-Ranvier G, Suh H, Stevenson M, Kinoshita Y, Donovan M, Antipin Y, Li Y, Liu X, Jin F, Wang P, Uzilov A, Argmann C, Schadt EE, Stewart AF, Scott DK, Lambertini L.
A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes. Sci Adv. 2020 Oct
Alvarsson A, Jimenez-Gonzalez M, Li R, Rosselot C, Tzavaras N, Wu Z, Stewart AF, Garcia-Ocaña A, Stanley SA.
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation. Nat Metab. 2020 May
Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN.
Fumihiko Urano
Washington University School of Medicine
urano@dom.wustl.edu
Neuroplastin Modulates Anti-inflammatory Effects of MANF. iScience. 2020 Nov
Yagi T, Asada R, Kanekura K, Eesmaa A, Lindahl M, Saarma M, Urano F.
Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly. J Endocr Soc. 2020 Sep
Stone SI, Wegner DJ, Wambach JA, Cole FS, Urano F, Ornitz DM.
Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome. Proc Natl Acad Sci U S A. 2020 Jul 21
Nguyen LD, Fischer TT, Abreu D, Arroyo A, Urano F, Ehrlich BE.
Bridget Wagner
Broad Institute
bwagner@broadinstitute.org
www.broadinstitute.org/group-wagner/chemical-biology-wagner-group
Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 2021 Mar
Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS;
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Sci Adv. 2020 Nov
Yang K, Lee M, Jones PA, Liu SS, Zhou A, Xu J, Sreekanth V, Wu JLY, Vo L, Lee EA, Pop R, Lee Y, Wagner BK, Melton DA, Choudhary A, Karp JM.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 2019 May
Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A.
Gordon Weir
Joslin Diabetes Center
gordon.weir@joslin.harvard.edu
www.joslin.org/research/research-sections/islet-cell-regenerative-biology
CellR4 Repair Replace Regen Reprogram. 2021
Weir GC, Bonner-Weir S. Why pancreatic islets should be regarded and regulated like organs.
Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability. Mol Metab. 2020 May
Ebrahimi AG, Hollister-Lock J, Sullivan BA, Tsuchida R, Bonner-Weir S, Weir GC.
Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes. Lancet Diabetes Endocrinol. 2020 Mar
Weir GC, Gaglia J, Bonner-Weir S.
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nat Metab. 2020 Sep
Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA, Melton DA, Kissler S, Yi P.